Fungiscope - Global Emerging Fungal Infection Registry

Global Emerging Fungal Infection Registry

Lupe

Associates

Chair
Prof. Oliver A. Cornely MD,
FACP, FIDSA, FAAM, FECMM, Cologne

Project Manager
Dr. Danila Seidel PhD,
Cologne

Coordinating Physicians and Quality Control Team Cologne
Dr. Jon Salmanton García PhD
Dr. Philipp Köhler MD
Dr. Jannik Stemler MD
Dr. Sibylle Mellinghoff MD
Stefanie Gräfe MD
Andrea Will

Epidemiology, IT & Statistics
Prof. J. Janne Vehreschild MD, FECMM, Cologne

Microbiology and Sample Storage
Dr. Hilmar Wisplinghoff MD,
Cologne

Molecular Identification
Dr. Volker Rickerts MD,
Berlin

Histopathology
Dr. Birgid Markiefka MD,
Cologne

Thoracic Surgery
Prof. Khosro Hekmat MD,
Cologne

Therapeutic Drug Monitoring
Dr. Carsten Müller MD,
Cologne

Publications

News

March 6, 2015

Today FDA approved isavuconazole for the treatment of invasive aspergillosis and invasive mucormycosis.

Here you can find the Astellas News Release.

While the aspergillosis indication is based on a large, well-designed randomized clinical trial, the mucormycosis indication is based single arm study results compared to literature data and a comparison with results from the ECMM FungiScope registry. For ECMM this is a unprecedented success in this area.

Oliver A. Cornely


Publications

Feb 2021
Sprute R, Salmanton-García J, Sal E, Malaj X, Ráčil Z, Ruiz de Alegría Puig C, Falces-Romero I, Barać A, Desoubeaux G, Jyoti Kindo A, Morris A J, Pelletier R, Steinmann J, Thompson G R, Cornely O A, Seidel D, Stemler J
Invasive infections with Purpureocillium lilacinum: clinical characteristics and outcome of 101 cases from FungiScope® and the literature
J Antimicrob Chemother. 2019 Feb.
Fulltext online
Feb 2021
Salmanton-García J, Sprute R, Stemler J, Bartoletti M, Dupont D, Valerio M, García-Vidal C, Falces-Romero I, Machado M, De la Villa S, Schroeder M, Hoyo I, Hanses F, Ferreira-Paim K, Roberto Giacobbe D, Meis JF, Gangneux JP, Rodríguez-Guardado A, Antinori S, Sal E, Malaj X, Seidel D, Cornely OA, Koehler P, FungiScope European Confederation of Medical Mycology/The International Society for Human and Animal Mycology Working Group
COVID-19-Associated Pulmonary Aspergillosis, March-August 2020
Emerg Infect Dis. 2019 Feb.
Fulltext online
Feb 2021
Hoenigl M, Salmanton-García J, Walsh TJ, Nucci M, Neoh CF, Jenks JD, Lackner M, Sprute R, Al-Hatmi AMS, Bassetti M, Carlesse F, Freiberger T, Koehler P, Lehrnbecher T, Kumar A, Prattes J, Richardson M, Revankar S, Slavin MA, Stemler J, Spiess B, Taj-Aldeen SJ, Warris A, Woo PCY, Young JH, Albus K, Arenz D, Arsic-Arsenijevic V, Bouchara JP, Chinniah TR, Chowdhary A, de Hoog GS, Dimopoulos G, Duarte RF, Hamal P, Meis JF, Mfinanga S, Queiroz-Telles F, Patterson TF, Rahav G, Rogers TR, Rotstein C, Wahyuningsih R, Seidel D, Cornely OA
Global guideline for the diagnosis and management of rare mould infections: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology and the American Society for Microbiology
Lancet Infect Dis. 2019 Feb.
Fulltext online
Feb 2021
Sprute R, Salmanton-García J, Sal E, Malaj X, Falces-Romero I, Hatvani L, Heinemann M, Klimko N, López-Soria L, Meletiadis J, Shruti M, Steinmann J, Seidel D, Cornely OA, Stemler J
Characterization and outcome of invasive infections due to Paecilomyces variotii: analysis of patients from the FungiScope® registry and literature reports
J Antimicrob Chemother. 2019 Feb.
Fulltext online
Jan 2021
Budin S, Salmanton-García J, Koehler P, Stemler J, Cornely OA, Mellinghoff SC
Validation of the EQUAL Aspergillosis Score by analysing guideline-adherent management of invasive pulmonary aspergillosis
J Antimicrob Chemother. 2019 Jan.
Fulltext online
Nov 2020
Salmanton-García J, Koehler P, Kindo A, Falces-Romero I, García-Rodríguez J, Ráčil Z, Chen SC, Klimko N, Desoubeaux G, Thompson GR , III, Benítez-Peñuela MÁ, Rodríguez JY, Sheppard DC, Hoenigl M, Le Govic Y, Badali H, Baddley JW, Chander J, Ingram PR, Pakstis DL, Mellinghoff SC, Atıcı S, Cesaro S, Chakrabarti A, Dupont D, González GM, Hatvani L, Herbrecht R, Klyasova G, Lass-Flörl C, Mareș M, Mullane K, Vinh DC, Wisplinghoff H, Lackner M, Cornely OA, Seidel D, ECMM/ISHAM working group
Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScope Ⓡ-Global Registry for Emerging Fungal Infections
J Infect. 2020 Nov.
Fulltext online
Oct 2020
Stemler J, Hamed K, Salmanton-García J, Rezaei-Matehkolaei A, Gräfe SK, Sal E, Zarrouk M, Seidel D, Abdelaziz Khedr R, Ben-Ami R, Ben-Chetrit E, Roth Y, Cornely OA
Mucormycosis in the Middle East and North Africa: Analysis of the FungiScope ® registry and cases from the literature
Mycoses. 2020 Oct.
Fulltext online
Apr 2020
Koehler P, Mellinghoff SC, Stemler J, Otte F, Berkhoff A, Beste N, Budin S, Cornely FB, Evans JM, Fuchs F, Pesch L, Rebholz AW, Reiner O, Schmitt M, Schuckelt J, Spiertz A, Salmanton-García J, Kron F, Cornely OA
Quantifying guideline adherence in mucormycosis management using the EQUAL score
Mycoses. 2020 Apr.
Fulltext online
Dec 2019
Seidel D, Hassler A, Salmanton-García J, Koehler P, Mellinghoff SC, Carlesse F, Cheng MP, Falces-Romero I, Herbrecht R, Jover Sáenz A, Klimko N, Mareş M, Lass-Flörl C, Soler-Palacín P, Wisplinghoff H, Cornely OA, Pana Z, Lehrnbecher T
Invasive Scedosporium spp. and Lomentospora prolificans infections in pediatric patients: Analysis of 55 cases from FungiScope® and the literature
Int J Infect Dis. 2019 Dec.
Fulltext online
Dec 2019
Stemler J, Salmanton-García J, Seidel D, Alexander BD, Bertz H, Hoenigl M, Herbrecht R, Meintker L, Meißner A, Mellinghoff SC, Sal E, Zarrouk M, Koehler P, Cornely OA
Risk factors and mortality in invasive Rasamsonia spp. infection: Analysis of cases in the FungiScope ® registry and from the literature
Mycoses. 2019 Dec.
Fulltext online
Oct 2019
Buchta V, Bolehovská R, Hovorková E, Cornely OA, Seidel D, Žák P
Saprochaete clavata Invasive Infections - A New Threat to Hematological-Oncological Patients
Front Microbiol. 2019 Oct.
Fulltext online
Aug 2019
Salmanton-García J, Seidel D, Koehler P, Mellinghoff SC, Herbrecht R, Klimko N, Ráčil Z, Falces-Romero I, Ingram P, Benítez-Peñuela MÁ, Rodríguez JY, Desoubeaux G, Barać A, García-Vidal C, Hoenigl M, Mehta SR, Cheng MP, Klyasova G, Heinz WJ, Iqbal N, Krause R, Ostermann H, Penack O, Schalk E, Sheppard DC, Willinger B, Wisplinghoff H, Vehreschild JJ, Cornely OA, Vehreschild MJGT; FungiScope® ECMM/ISHAM Working Group
Matched-paired analysis of patients treated for invasive mucormycosis: standard treatment versus posaconazole new formulations (MoveOn).
J Antimicrob Chemother. 2019 Aug.
Fulltext online
Aug 2019
Koehler P, Salmanton-García J, Gräfe SK, Koehler FC, Mellinghoff SC, Seidel D, Steinbach A, Cornely OA
Baseline predictors influencing the prognosis of invasive aspergillosis in adults
Mycoses. 2019 Aug.
Fulltext online
Jan 2019
Seidel D, Meißner A, Lackner M, Piepenbrock E, Salmanton-García J, Stecher M, Mellinghoff S, Hamprecht A, Durán Graeff L, Köhler P, Cheng MP, Denis J, Chedotal I, Chander J, Pakstis DL, Los-Arcos I, Slavin M, Montagna MT, Caggiano G, Mares M, Trauth J, Aurbach U, Vehreschild MJGT, Vehreschild JJ, Duarte RF, Herbrecht R, Wisplinghoff H, Cornely OA; FungiScope Group
Prognostic factors in 264 adults with invasive Scedosporium spp. and Lomentospora prolificans infection reported in the literature and FungiScope®.
Critical Reviews in Microbiology. 2019 Jan.
Fulltext online
July 2017
Seidel D, Durán Graeff L, Vehreschild MJGT, Wisplinghoff H, Ziegler M, Vehreschild JJ, Liss B, Hamprecht A, Köhler P, Racil Z, Klimko N, Sheppard D, Herbrecht R, Chowdhary A, Cornely OA; FungiScope Group
FungiScope™ — Global Emerging Fungal Infection Registry.
Mycoses. 2017 Jul.
Fulltext online
January 2017
Durán Graeff L, Seidel D, Vehreschild MJGT, Hamprecht A, Kindo A, Racil Z, Demeter J, De Hoog S, Aurbach U, Ziegler M, Wisplinghoff H, Cornely OA; FungiScope Group
Invasive infections due to Saprochaete and Geotrichum species: Report of 23 cases from the FungiScope Registry.
Mycoses. 2017 Jan.
Fulltext online
November 2016
Hassler A, Lieb A, Seidel D, Simone Cesaro S, Greil J, Klimko N, Khostelidi S, Solopova G, Ogunc D, Durán Graeff L, Cornely OA, Vehreschild MJGT, Lehrnbecher T.
Disseminated Fusariosis in Immunocompromised Children - Analysis of Recent Cases Identified in the Global FungiScope Registry.
Pediatr Infect Dis J. 2016 Nov 11.
Fulltext online
November 2016
Pana ZD, Seidel D, Skiada A, Groll AH, Petrikkos G, Cornely OA, Roilides E; Collaborators of Zygomyco.net and/or FungiScope™ Registries.
Invasive mucormycosis in children: an epidemiologic study in European and non-European countries based on two registries.
BMC Infect Dis. 2016 Nov 10;16(1):667.
Fulltext online
August 2016
Cornely OA, Maher RM, Marty FM, Lee M, Vehreschild JJ, Vehreschild MJ.
The VITAL study: case control studies are hypothesis-generating.
Lancet Infect Dis. 2016 Aug;16(8):886-7.
Fulltext online
March 2016
Marty FM, Ostrosky-Zeichner L, Cornely OA, Mullane KM, Perfect JR, Thompson GR 3rd, Alangaden GJ, Brown JM, Fredricks DN, Heinz WJ, Herbrecht R, Klimko N, Klyasova G, Maertens JA, Melinkeri SR, Oren I, Pappas PG, Ráčil Z, Rahav G, Santos R, Schwartz S, Vehreschild JJ, Young JA, Chetchotisakd P, Jaruratanasirikul S, Kanj SS, Engelhardt M, Kaufhold A, Ito M, Lee M, Sasse C, Maher RM, Zeiher B, Vehreschild MJ; VITAL and FungiScope Mucormycosis Investigators.
Isavuconazole treatment for mucormycosis: a single-arm open-label trial and case-control analysis.
Lancet Infect Dis. 2016 Jul;16(7):828-37. Epub 2016 Mar 9.
Fulltext online
October 2013
Nucci M, Marr K, Vehreschild M, de Souza C, Velasco E, Cappelano P, Carlesse F, Queiroz-Telles F, Sheppard D, Kindo A, Cesaro S, Hamerschlak N, Solza C, Heinz W, Schaller M, Atalla A, Arikan-Akdagli S, Bertz H, Castro Jr C, Herbrecht R, Hoenigl M, Härter G, Hermansen NE, Josting A, Pagano L, Salles M, Mossad SB, Ogunc D, Pasqualotto A, Araujo V, Troke P, Lortholary O, Cornely O, Anaissie E.
Improvement in the outcome of invasive fusariosis in the last decade.
Clin Microbiol Infect. 2014 Jun;20(6):580-5
Fulltext online
May 2013
Pagano L, Cornely O, Caira M, Cesaro S, Gasbarrino C, Girmenia C, Heinz WJ, Herbrecht R, Lass-Flörl C, Nosari A, Potenza L, Racil Z, Rickerts V, Sheppard DC, Simon A, Ullmann AJ, Valentini CG, Vehreschild JJ, Candoni A, Vehreschild MJ.
Combined antifungal approach for the treatment of invasive mucormycosis in patients with hematological diseases: a report from the SEIFEM and FUNGISCOPE registries.
Haematologica 2013 May 28
Fulltext online
January 2013
Christopeit M, Lindner A, Surov A, Weber T, Vehreschild MJ, Bialek R, Schmoll HJ.
Right flank pain and high fever in a neutropenic patient with acute lymphoblastic leukaemia.
Mycoses 2013, Jan; 56(1):90-92
Fulltext online
October 2011
de Hoog GS, Robert V, Lackner M, Vehreschild MJ, Vehreschild JJ, Symoens F, Göttlich-Fligg E, Garcia-Hermoso D, Harun A, Meyer W, Chen SC, Hamprecht A, Fischer G, Buzina W, Cornely OA, Guarro J, Cano J, Horré R.
Making moulds meet. Information retrieval as a basis for understanding Pseudallescheria and Scedosporium.
Mycoses 2011, Oct;54 Suppl 3:1-4
Fulltext online
December 2009
Rüping MJGT, Heinz WJ, Kindo AJ, Rickerts V, Lass-Flörl C, Beisel C, Herbrecht R, Roth Y, Silling G, Ullmann AJ, Borchert K, Egerer G, Maertens J, Maschmeyer G, Simon A, Wattad M, Fischer G, Vehreschild JJ, Cornely OA.
Forty-one Recent Cases of Invasive Zygomycosis from a Global Clinical Registry.
J Antimicrob Chemother 2010, Feb;65(2):296-302
Fulltext online
July 2008
Rüping MJGT, Albermann N, Ebinger F, Burckhard I, Beisel C, Müller C, Vehreschild JJ, Kochanek M, Fätkenheuer G, Bangard C, Ullmann AJ, Herr W, Kolbe K, Hallek M, Cornely OA.
Posaconazole concentrations in the central nervous system.
J Antimicrob Chemother 2008, Dec;62 (6):1468-70
Fulltext online

Presentations 2010 - 2019

2019, Jun 20 - 24
ASM Microbe, San Francisco, USA (Poster MoveOn)
2019, Apr 13 - 16
29th ECCMID, Amsterdam, Netherlands (ESCMID Networking Corner FungiScope, Poster MoveOn)
2018, Dec 03 - 04
DZIF Annual Meeting, Heidelberg, Germany (Poster MoveOn)
2018, Oct 03 - 07
IDWeek 2018, San Francisco, USA (Posters: FungiScope and Scedosporium and Lomentospora-related infections)
2018, Sept 25 - 28
MSGERC Biennial Meeting, Big Sky, Montana USA (Poster FungiScope)
2018, Sep 5 - 7
53rd Scientific Conference of the German speaking Mycological Society (DMykG), Innsbruck, Switzerland (Oral FungiScope and Scedosporium and Lomentospora-related infections)
2018, Jun 30 - Jul 04
ISHAM, Amsterdam, Netherlands (Oral FungiScope)
2018, Apr 21 - 24
28th ECCMID, Madrid, Spain (ESCMID Networking Corner FungiScope, Poster Scedosporium and Lomentospora-related infections)
2017, Oct 06 - 09
8th Trends in Medical Mycology (TIMM), Belgrade, Serbia (Posters FungiScope and MoveOn)
2017, Apr 22 - 25
27th ECCMID, Vienna, Austria (ESCMID Networking Corner FungiScope)
2017, Mar 26 - 29
43rd EBMT Annual Meeting, Marseille, France (Poster FungiScope)
2016, Oct 26 - 30
IDWeek 2016, New Orleans, USA (Oral Posaconazole for mucormycosis)
2016, Oct 14 - 18
Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie 2016, Leipzig, Germany
2016, Apr 9 - 12
26th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), ESCMID Networking Corner 2016, Amsterdam, The Netherlands Poster
2016, Jan 27 – 29
European Confederation of Medical Mycology (ECMM) Transdisciplinary Workshop on Antifungal Stewardship, Wesel, Germany
2015, Nov 19 – 21
Joint DGI and DZIF Annual Meeting, Munich, Germany
2015, Oct 9 – 13
Annual Congress of the DGHO, OeGHO, SGMO und SGH, Basel, Schweiz
2015, Oct 9 – 12
7th Trends in Medical Mycology (TIMM), Lisbon, Portugal
2015, Sept 17 – 21
55th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Diego, USA
2015, April 25 – 28
25th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Kopenhagen, Denmark Poster
2015, Mar 19 – 21
ESCMID Postgraduate Education Course - Diagnosis and Management of Fungal Infections Both in the West and the East, Delhi, India Talk
2014, Oct 13 – 15
Research for Rare - Translational Science Meeting, Munich, Germany Poster
2014, Sept 5 – 9
54th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Washington, USA
2014, June 25 – 28
Kongress für Infektionskrankheiten und Tropenmedizin (KIT), Cologne, Germany
2014, June 15 – 16
Symposium on Infections in the Immunocompromised Hosts, International Immunocompromised Host Society (ICHS), Berlin, Germany
2014, May 10 – 13
24th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Barcelona, Spain
2014, Jan 10 – 12
10th National Conference of the Society for Indian Human and Animal Mycologists (SIHAM), Coimbatore, Tamil Nadu, India
2013, Oct 11 – 14
6th Trends in Medical Mycology (TIMM), Copenhagen, Denmark
2013, Sept 22 – 25
Joint Annual Meeting of the German Society for Hygiene and Microbiology and the German Society for Infectious Diseases (DGI), Rostock, Germany
2013, Sept 9 – 13
53rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Denver, CO, USA
2013, Sept 5 – 7
47th Congress of the German Society for Mycology (DMykG e.V.), Tübingen, Germany
2013, Apr 27 – 30
23rd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Berlin, Germany
2012, Oct 19 - 23
Annual Congress of the German Society for Hematology and Oncology (DGHO), Stuttgart, Germany
2012, Sept 9 - 12
52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Francisco, CA, USA
2012, June 23 - 26
18th Congress of the International Society for Human and Animal Mycology, Berlin, Germany
2012, Apr 25 - 28
11th Congress of Infectious Diseases and Tropical Medicine, Cologne, Germany
2012, Mar 31 - Apr 3
22nd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), London, UK
2012, Jan 24 - 25
3rd WATL-Congress, Berlin, Germany
2011, Oct 2 - 5
5th Trends in Medical Mycology (TIMM), Valencia, Spain
2011, Sept 30 - Oct 4
Annual Congress of the German Society for Hematology and Oncology (DGHO), Basel, Switzerland
2011, Sept 17 - 21
51th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Chicago, USA
2011, Sept 1 - 3
45th Congress of the German Society for Mycology (DMykG e.V.), Kiel, Germany
2011, May 7 - 10
21st ECCMID/27th ICC, Joint Congress of the European Society of Clinical Microbiology and Infectious Diseases and the International Society of Chemotherapy 20th, Milan, Italy
2011, Mar 31 - Apr 2
Annual Congress of the German Society for Infectious Diseases (DGI), Leipzig, Germany
2010, Oct 1 - 5
Annual Congress of the German Society for Hematology and Oncology (DGHO), Berlin, Germany
2010, Sept 12 - 15
50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), MA, Boston, USA
2010, Sept 9 - 11
44th Congress of the German Society for Mycology (DMykG e.V.), Vienna, Austria
2010, June 23 - 26
10th Congress of Infectious Diseases and Tropical Medicine, Cologne, Germany
2010, June 18 - 19
MSD Workshop Infektionen in der Hämatologie, Munich, Germany
2010, May 7 - 8
Paul-Ehrlich-Gesellschaft für Chemotherapie e.V., Spring Meeting of the Sektion Antimykotische Chemotherapie, Bonn, Germany
2010, Apr 10 - 13
20th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Vienna, Austria