Fungiscope

Associates

Chair
Prof. Oliver A. Cornely MD,
FACP, FIDSA, FAAM, FECMM, Cologne

Scientific Lead
Dr. Danila Seidel PhD,
Cologne

Project Manager
Natalia Vasenda MSc,
Cologne

Coordinating Physicians and Quality Control Team Cologne
Dr. Philipp Köhler MD
Dr. Jon Salmanton-García PhD
Dr. Rosanne Sprute MD
Dr. Jannik Stemler MD
Dr. Sibylle Mellinghoff MD
Stefanie Gräfe MD
Andrea Will

Epidemiology, IT & Statistics
Prof. J. Janne Vehreschild MD, FECMM, Cologne

Microbiology and Sample Storage
Dr. Hilmar Wisplinghoff MD,
Cologne

Molecular Identification
Dr. Volker Rickerts MD,
Berlin

Histopathology
Dr. Birgid Markiefka MD,
Cologne

Thoracic Surgery
Prof. Khosro Hekmat MD,
Cologne

Therapeutic Drug Monitoring
Dr. Carsten Müller MD,
Cologne

Publications

News

March 6, 2015

Today FDA approved isavuconazole for the treatment of invasive aspergillosis and invasive mucormycosis.

Here you can find the Astellas News Release.

While the aspergillosis indication is based on a large, well-designed randomized clinical trial, the mucormycosis indication is based single arm study results compared to literature data and a comparison with results from the ECMM FungiScope registry. For ECMM this is a unprecedented success in this area.

Oliver A. Cornely

Publications

Aug 2021: Hoenigl M, Salmanton-García J, Walsh TJ, Nucci M, Neoh CF, Jenks JD, Lackner M, Sprute R, Al-Hatmi AMS, Bassetti M, Carlesse F, Freiberger T, Koehler P, Lehrnbecher T, Kumar A, Prattes J, Richardson M, Revankar S, Slavin MA, Stemler J, Spiess B, Taj-Aldeen SJ, Warris A, Woo PCY, Young JH, Albus K, Arenz D, Arsic-Arsenijevic V, Bouchara JP, Chinniah TR, Chowdhary A, de Hoog GS, Dimopoulos G, Duarte RF, Hamal P, Meis JF, Mfinanga S, Queiroz-Telles F, Patterson TF, Rahav G, Rogers TR, Rotstein C, Wahyuningsih R, Seidel D, Cornely OA
Global guideline for the diagnosis and management of rare mould infections: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology and the American Society for Microbiology
Lancet Infect Dis. 2021 Aug.
Fulltext online
Jun 2021: Koehler P, Bassetti M, Chakrabarti A, Chen SCA, Colombo AL, Hoenigl M, Klimko N, Lass-Flörl C, Oladele RO, Vinh DC, Zhu LP, Böll B, Brüggemann R, Gangneux JP, Perfect JR, Patterson TF, Persigehl T, Meis JF, Ostrosky-Zeichner L, White PL, Verweij PE, Cornely OA; European Confederation of Medical Mycology; International Society for Human Animal Mycology; Asia Fungal Working Group; INFOCUS LATAM/ISHAM Working Group; ISHAM Pan Africa Mycology Working Group; European Society for Clinical Microbiology; Infectious Diseases Fungal Infection Study Group; ESCMID Study Group for Infections in Critically Ill Patients; Interregional Association of Clinical Microbiology and Antimicrobial Chemotherapy; Medical Mycology Society of Nigeria; Medical Mycology Society of China Medicine Education Association; Infectious Diseases Working Party of the German Society for Haematology and Medical Oncology; Association of Medical Microbiology; Infectious Disease Canada
Defining and managing COVID-19-associated pulmonary aspergillosis: the 2020 ECMM/ISHAM consensus criteria for research and clinical guidance
Lancet Infect Dis. 2021 Jun.
Fulltext online
Jun 2021: Jeck J, Wingen-Heimann SM, Thielscher C, Kron A, Bonn J, Jakobs F, Grau S, Enoch DA, Micallef C, Cornely OA, Kron F
Reimbursement of innovative pharmaceuticals in English and Spanish hospitals-The example of isavuconazole
Mycoses 2021 Jun.
Fulltext online
May 2021: Sprute R, Salmanton-García J, Sal E, Malaj X, Ráčil Z, Ruiz de Alegría Puig C, Falces-Romero I, Barać A, Desoubeaux G, Jyoti Kindo A, Morris A J, Pelletier R, Steinmann J, Thompson G R, Cornely O A, Seidel D, Stemler J
Invasive infections with Purpureocillium lilacinum: clinical characteristics and outcome of 101 cases from FungiScope® and the literature
J Antimicrob Chemother. 2021 May.
Fulltext online
Mar 2021: Banck JC, Mueller N, Mellinghoff SC, Thelen M, Fraccaroli A, Blumenberg V, Koehler P, Kunz WG, Rudelius M, Schrötzlmair F, Subklewe M, Schlößer HA, Tischer J, Cornely OA, Lindner LH, von Bergwelt-Baildon M
Immune Checkpoint Blockade for Aspergillosis and Mucormycosis Coinfection
Hemasphere 2021 Mar.
Fulltext online
Feb 2021: Salmanton-García J, Sprute R, Stemler J, Bartoletti M, Dupont D, Valerio M, García-Vidal C, Falces-Romero I, Machado M, De la Villa S, Schroeder M, Hoyo I, Hanses F, Ferreira-Paim K, Roberto Giacobbe D, Meis JF, Gangneux JP, Rodríguez-Guardado A, Antinori S, Sal E, Malaj X, Seidel D, Cornely OA, Koehler P, FungiScope European Confederation of Medical Mycology/The International Society for Human and Animal Mycology Working Group
COVID-19-Associated Pulmonary Aspergillosis, March-August 2020
Emerg Infect Dis. 2021 Feb.
Fulltext online
Feb 2021: Hoenigl M, Salmanton-García J, Walsh TJ, Nucci M, Neoh CF, Jenks JD, Lackner M, Sprute R, Al-Hatmi AMS, Bassetti M, Carlesse F, Freiberger T, Koehler P, Lehrnbecher T, Kumar A, Prattes J, Richardson M, Revankar S, Slavin MA, Stemler J, Spiess B, Taj-Aldeen SJ, Warris A, Woo PCY, Young JH, Albus K, Arenz D, Arsic-Arsenijevic V, Bouchara JP, Chinniah TR, Chowdhary A, de Hoog GS, Dimopoulos G, Duarte RF, Hamal P, Meis JF, Mfinanga S, Queiroz-Telles F, Patterson TF, Rahav G, Rogers TR, Rotstein C, Wahyuningsih R, Seidel D, Cornely OA
Global guideline for the diagnosis and management of rare mould infections: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology and the American Society for Microbiology
Lancet Infect Dis. 2021 Feb.
Fulltext online
Feb 2021: Sprute R, Salmanton-García J, Sal E, Malaj X, Falces-Romero I, Hatvani L, Heinemann M, Klimko N, López-Soria L, Meletiadis J, Shruti M, Steinmann J, Seidel D, Cornely OA, Stemler J
Characterization and outcome of invasive infections due to Paecilomyces variotii: analysis of patients from the FungiScope® registry and literature reports
J Antimicrob Chemother. 2021 Feb.
Fulltext online
Feb 2021: Hoenigl M, Levitz SM, Schuetz AN, Zhang SX, Cornely OA
All You Need to Know and More about the Diagnosis and Management of Rare Mold Infections
mBio. 2021 Feb.
Fulltext online
Feb 2021: Sprute R, Seidel D, Cornely OA, Hoenigl M
EHA Endorsement of the Global Guideline for the Diagnosis and Management of Rare Mold Infection: An Initiative of the European Confederation of Medical Mycology in Cooperation With International Society for Human and Animal Mycology and American Society for Microbiology
Hemasphere. 2021 Feb.
Fulltext online
Jan 2021: Budin S, Salmanton-García J, Koehler P, Stemler J, Cornely OA, Mellinghoff SC
Validation of the EQUAL Aspergillosis Score by analysing guideline-adherent management of invasive pulmonary aspergillosis
J Antimicrob Chemother. 2021 Jan.
Fulltext online
Jan 2021: Zhang J, Zhang Y, Wu D, Cao G, Hamed K, Desai A, Aram JA, Guo X, Fayyad R, Cornely OA
Clinical experience with isavuconazole in healthy volunteers and patients with invasive aspergillosis in China, and the results from an exposure-response analysis
Mycoses 2021 Jan.
Fulltext online
Nov 2020: Salmanton-García J, Koehler P, Kindo A, Falces-Romero I, García-Rodríguez J, Ráčil Z, Chen SC, Klimko N, Desoubeaux G, Thompson GR , III, Benítez-Peñuela MÁ, Rodríguez JY, Sheppard DC, Hoenigl M, Le Govic Y, Badali H, Baddley JW, Chander J, Ingram PR, Pakstis DL, Mellinghoff SC, Atıcı S, Cesaro S, Chakrabarti A, Dupont D, González GM, Hatvani L, Herbrecht R, Klyasova G, Lass-Flörl C, Mareș M, Mullane K, Vinh DC, Wisplinghoff H, Lackner M, Cornely OA, Seidel D, ECMM/ISHAM working group
Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScope Ⓡ-Global Registry for Emerging Fungal Infections
J Infect. 2020 Nov.
Fulltext online
Oct 2020: Stemler J, Hamed K, Salmanton-García J, Rezaei-Matehkolaei A, Gräfe SK, Sal E, Zarrouk M, Seidel D, Abdelaziz Khedr R, Ben-Ami R, Ben-Chetrit E, Roth Y, Cornely OA
Mucormycosis in the Middle East and North Africa: Analysis of the FungiScope ® registry and cases from the literature
Mycoses. 2020 Oct.
Fulltext online
Jun 2020: Koehler P, Denis B, Denning DW, Gangneux JP, Hoenigl M, Kontoyiannis DP, Krause R, Lagrou K, Lass-Flörl C, Maertens J, Mareković I, Meis JF, Molina JM, Pleško S, Prattes J, Rath PM, Rautemaa-Richardson R, Richardson M, Segal E, Seidel D, Spriet I, Steinmann J, Verweij PE, Cornely OA; European Confederation of Medical Mycology (ECMM)
European confederation of medical mycology expert consult-An ECMM excellence center initiative
Mycoses. 2020 Jun.
Fulltext online
Jun 2020: Koehler P, Cornely OA, Böttiger BW, Dusse F, Eichenauer DA, Fuchs F, Hallek M, Jung N, Klein F, Persigehl T, Rybniker J, Kochanek M, Böll B, Shimabukuro-Vornhagen A
COVID-19 associated pulmonary aspergillosis
Mycoses. 2020 Jun.
Fulltext online
Jun 2020: Jenks JD, Seidel D, Cornely OA, Chen S, van Hal S, Kauffman C, Miceli MH, Heinemann M, Christner M, Jover Sáenz A, Burchardt A, Kemmerling B, Herbrecht R, Steinmann J, Shoham S, Gräber S, Pagano L, Deeren D, Aslam S, Taplitz R, Revankar SG, Baddley J, Mehta SR, Reed S, Slavin MA, Hoenigl M
Voriconazole plus terbinafine combination antifungal therapy for invasive Lomentospora prolificans infections: analysis of 41 patients from the FungiScope® registry 2008-2019
Clin Microbiol Infect. 2020 Jun.
Fulltext online
May 2020: Jenks JD, Seidel D, Cornely OA, Chen S, van Hal S, Kauffman C, Miceli MH, Heinemann M, Christner M, Jover Sáenz A, Burchardt A, Kemmerling B, Herbrecht R, Steinmann J, Shoham S, Gräber S, Pagano L, Deeren D, Slavin MA, Hoenigl M
Clinical characteristics and outcomes of invasive Lomentospora prolificans infections: Analysis of patients in the FungiScope ® registry
Mycoses. 2020 May.
Fulltext online
Apr 2020: Koehler P, Mellinghoff SC, Stemler J, Otte F, Berkhoff A, Beste N, Budin S, Cornely FB, Evans JM, Fuchs F, Pesch L, Rebholz AW, Reiner O, Schmitt M, Schuckelt J, Spiertz A, Salmanton-García J, Kron F, Cornely OA
Quantifying guideline adherence in mucormycosis management using the EQUAL score
Mycoses. 2020 Apr.
Fulltext online
Mar 2020: Seidel D, Hassler A, Salmanton-García J, Koehler P, Mellinghoff SC, Carlesse F, Cheng MP, Falces-Romero I, Herbrecht R, Jover Sáenz A, Klimko N, Mareş M, Lass-Flörl C, Soler-Palacín P, Wisplinghoff H, Cornely OA, Pana Z, Lehrnbecher T
Invasive Scedosporium spp. and Lomentospora prolificans infections in pediatric patients: Analysis of 55 cases from FungiScope® and the literature
Int J Infect Dis. 2020 Mar.
Fulltext online
Mar 2020: Stemler J, Salmanton-García J, Seidel D, Alexander BD, Bertz H, Hoenigl M, Herbrecht R, Meintker L, Meißner A, Mellinghoff SC, Sal E, Zarrouk M, Koehler P, Cornely OA
Risk factors and mortality in invasive Rasamsonia spp. infection: Analysis of cases in the FungiScope ® registry and from the literature
Mycoses. Mar 2020.
Fulltext online
Nov 2019: Salmanton-García J, Seidel D, Koehler P, Mellinghoff SC, Herbrecht R, Klimko N, Ráčil Z, Falces-Romero I, Ingram P, Benítez-Peñuela MÁ, Rodríguez JY, Desoubeaux G, Barać A, García-Vidal C, Hoenigl M, Mehta SR, Cheng MP, Klyasova G, Heinz WJ, Iqbal N, Krause R, Ostermann H, Penack O, Schalk E, Sheppard DC, Willinger B, Wisplinghoff H, Vehreschild JJ, Cornely OA, Vehreschild MJGT; FungiScope® ECMM/ISHAM Working Group.
Matched-paired analysis of patients treated for invasive mucormycosis: standard treatment versus posaconazole new formulations (MoveOn)
J Antimicrob Chemother. 2019 Nov.
Fulltext online
Oct 2019: Buchta V, Bolehovská R, Hovorková E, Cornely OA, Seidel D, Žák P
Saprochaete clavata Invasive Infections - A New Threat to Hematological-Oncological Patients
Front Microbiol. 2019 Oct.
Fulltext online
Aug 2019: Salmanton-García J, Seidel D, Koehler P, Mellinghoff SC, Herbrecht R, Klimko N, Ráčil Z, Falces-Romero I, Ingram P, Benítez-Peñuela MÁ, Rodríguez JY, Desoubeaux G, Barać A, García-Vidal C, Hoenigl M, Mehta SR, Cheng MP, Klyasova G, Heinz WJ, Iqbal N, Krause R, Ostermann H, Penack O, Schalk E, Sheppard DC, Willinger B, Wisplinghoff H, Vehreschild JJ, Cornely OA, Vehreschild MJGT; FungiScope® ECMM/ISHAM Working Group
Matched-paired analysis of patients treated for invasive mucormycosis: standard treatment versus posaconazole new formulations (MoveOn).
J Antimicrob Chemother. 2019 Aug.
Fulltext online
Aug 2019: Koehler P, Salmanton-García J, Gräfe SK, Koehler FC, Mellinghoff SC, Seidel D, Steinbach A, Cornely OA
Baseline predictors influencing the prognosis of invasive aspergillosis in adults
Mycoses. 2019 Aug.
Fulltext online
Mar 2019: Koehler P, Salmanton-García J, Gräfe SK, Koehler FC, Mellinghoff SC, Seidel D, Steinbach A, Cornely OA
Healthcare burden of probable and proven invasive mucormycosis: a multi-centre cost-of-illness analysis of patients treated in tertiary care hospitals between 2003 and 2016
J Hosp Infect. 2019 Mar.
Fulltext online
Feb 2019: Seidel D, Meißner A, Lackner M, Piepenbrock E, Salmanton-García J, Stecher M, Mellinghoff S, Hamprecht A, Durán Graeff L, Köhler P, Cheng MP, Denis J, Chedotal I, Chander J, Pakstis DL, Los-Arcos I, Slavin M, Montagna MT, Caggiano G, Mares M, Trauth J, Aurbach U, Vehreschild MJGT, Vehreschild JJ, Duarte RF, Herbrecht R, Wisplinghoff H, Cornely OA; FungiScope Group
Prognostic factors in 264 adults with invasive Scedosporium spp. and Lomentospora prolificans infection reported in the literature and FungiScope®.
Critical Reviews in Microbiology. 2019 Feb.
Fulltext online
July 2017: Seidel D, Durán Graeff L, Vehreschild MJGT, Wisplinghoff H, Ziegler M, Vehreschild JJ, Liss B, Hamprecht A, Köhler P, Racil Z, Klimko N, Sheppard D, Herbrecht R, Chowdhary A, Cornely OA; FungiScope Group
FungiScope™ — Global Emerging Fungal Infection Registry.
Mycoses. 2017 Jul.
Fulltext online
January 2017: Durán Graeff L, Seidel D, Vehreschild MJGT, Hamprecht A, Kindo A, Racil Z, Demeter J, De Hoog S, Aurbach U, Ziegler M, Wisplinghoff H, Cornely OA; FungiScope Group
Invasive infections due to Saprochaete and Geotrichum species: Report of 23 cases from the FungiScope Registry.
Mycoses. 2017 Jan.
Fulltext online
November 2016: Hassler A, Lieb A, Seidel D, Simone Cesaro S, Greil J, Klimko N, Khostelidi S, Solopova G, Ogunc D, Durán Graeff L, Cornely OA, Vehreschild MJGT, Lehrnbecher T.
Disseminated Fusariosis in Immunocompromised Children - Analysis of Recent Cases Identified in the Global FungiScope Registry.
Pediatr Infect Dis J. 2016 Nov 11.
Fulltext online
November 2016: Pana ZD, Seidel D, Skiada A, Groll AH, Petrikkos G, Cornely OA, Roilides E; Collaborators of Zygomyco.net and/or FungiScope™ Registries.
Invasive mucormycosis in children: an epidemiologic study in European and non-European countries based on two registries.
BMC Infect Dis. 2016 Nov 10;16(1):667.
Fulltext online
August 2016: Cornely OA, Maher RM, Marty FM, Lee M, Vehreschild JJ, Vehreschild MJ.
The VITAL study: case control studies are hypothesis-generating.
Lancet Infect Dis. 2016 Aug;16(8):886-7.
Fulltext online
March 2016: Marty FM, Ostrosky-Zeichner L, Cornely OA, Mullane KM, Perfect JR, Thompson GR 3rd, Alangaden GJ, Brown JM, Fredricks DN, Heinz WJ, Herbrecht R, Klimko N, Klyasova G, Maertens JA, Melinkeri SR, Oren I, Pappas PG, Ráčil Z, Rahav G, Santos R, Schwartz S, Vehreschild JJ, Young JA, Chetchotisakd P, Jaruratanasirikul S, Kanj SS, Engelhardt M, Kaufhold A, Ito M, Lee M, Sasse C, Maher RM, Zeiher B, Vehreschild MJ; VITAL and FungiScope Mucormycosis Investigators.
Isavuconazole treatment for mucormycosis: a single-arm open-label trial and case-control analysis.
Lancet Infect Dis. 2016 Jul;16(7):828-37. Epub 2016 Mar 9.
Fulltext online
October 2013: Nucci M, Marr K, Vehreschild M, de Souza C, Velasco E, Cappelano P, Carlesse F, Queiroz-Telles F, Sheppard D, Kindo A, Cesaro S, Hamerschlak N, Solza C, Heinz W, Schaller M, Atalla A, Arikan-Akdagli S, Bertz H, Castro Jr C, Herbrecht R, Hoenigl M, Härter G, Hermansen NE, Josting A, Pagano L, Salles M, Mossad SB, Ogunc D, Pasqualotto A, Araujo V, Troke P, Lortholary O, Cornely O, Anaissie E.
Improvement in the outcome of invasive fusariosis in the last decade.
Clin Microbiol Infect. 2014 Jun;20(6):580-5
Fulltext online
May 2013: Pagano L, Cornely O, Caira M, Cesaro S, Gasbarrino C, Girmenia C, Heinz WJ, Herbrecht R, Lass-Flörl C, Nosari A, Potenza L, Racil Z, Rickerts V, Sheppard DC, Simon A, Ullmann AJ, Valentini CG, Vehreschild JJ, Candoni A, Vehreschild MJ.
Combined antifungal approach for the treatment of invasive mucormycosis in patients with hematological diseases: a report from the SEIFEM and FUNGISCOPE registries.
Haematologica 2013 May 28
Fulltext online
January 2013: Christopeit M, Lindner A, Surov A, Weber T, Vehreschild MJ, Bialek R, Schmoll HJ.
Right flank pain and high fever in a neutropenic patient with acute lymphoblastic leukaemia.
Mycoses 2013, Jan; 56(1):90-92
Fulltext online
October 2011: de Hoog GS, Robert V, Lackner M, Vehreschild MJ, Vehreschild JJ, Symoens F, Göttlich-Fligg E, Garcia-Hermoso D, Harun A, Meyer W, Chen SC, Hamprecht A, Fischer G, Buzina W, Cornely OA, Guarro J, Cano J, Horré R.
Making moulds meet. Information retrieval as a basis for understanding Pseudallescheria and Scedosporium.
Mycoses 2011, Oct;54 Suppl 3:1-4
Fulltext online
December 2009: Rüping MJGT, Heinz WJ, Kindo AJ, Rickerts V, Lass-Flörl C, Beisel C, Herbrecht R, Roth Y, Silling G, Ullmann AJ, Borchert K, Egerer G, Maertens J, Maschmeyer G, Simon A, Wattad M, Fischer G, Vehreschild JJ, Cornely OA.
Forty-one Recent Cases of Invasive Zygomycosis from a Global Clinical Registry.
J Antimicrob Chemother 2010, Feb;65(2):296-302
Fulltext online
July 2008: Rüping MJGT, Albermann N, Ebinger F, Burckhard I, Beisel C, Müller C, Vehreschild JJ, Kochanek M, Fätkenheuer G, Bangard C, Ullmann AJ, Herr W, Kolbe K, Hallek M, Cornely OA.
Posaconazole concentrations in the central nervous system.
J Antimicrob Chemother 2008, Dec;62 (6):1468-70
Fulltext online

Global Emerging Fungal Infection Registry

Associates

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News

Publications

Presentations 2010 - 2019